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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
23.33
Human Site:
T84
Identified Species:
42.78
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
T84
R
H
F
K
L
Y
L
T
S
S
T
E
R
F
S
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
T84
R
H
F
K
L
Y
L
T
S
S
T
E
R
F
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
R80
F
V
H
R
V
K
R
R
A
D
P
N
P
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
T84
R
H
F
K
L
Y
L
T
S
S
T
E
R
F
S
Rat
Rattus norvegicus
Q9Z1K9
827
92999
T84
R
H
F
K
L
Y
L
T
S
S
T
E
R
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
Chicken
Gallus gallus
NP_001008682
829
93588
T84
R
H
F
K
L
Y
L
T
A
T
A
E
H
F
S
Frog
Xenopus laevis
Q8JIY1
749
84049
R73
H
G
R
Q
F
N
L
R
M
K
K
D
T
S
L
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
T81
R
H
F
K
L
Y
L
T
T
N
T
E
L
F
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
N61
K
H
S
T
N
P
F
N
T
I
K
E
V
E
F
Honey Bee
Apis mellifera
XP_623993
716
82155
I45
S
Y
H
P
Y
N
K
I
N
E
L
E
F
Y
S
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
G15
L
L
I
F
L
V
L
G
I
L
K
S
D
A
F
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
T76
K
R
E
G
L
F
T
T
D
F
S
V
Y
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
100
N.A.
0
N.A.
100
100
N.A.
0
73.3
6.6
73.3
N.A.
13.3
13.3
13.3
13.3
P-Site Similarity:
100
100
N.A.
20
N.A.
100
100
N.A.
0
86.6
20
93.3
N.A.
26.6
33.3
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
16
0
8
0
0
16
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
8
0
8
8
0
0
% D
% Glu:
0
0
8
0
0
0
0
0
0
8
0
62
0
8
0
% E
% Phe:
8
0
47
8
8
8
8
0
0
8
0
0
8
47
16
% F
% Gly:
0
8
0
8
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
8
54
16
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
0
0
8
8
8
0
0
0
0
0
% I
% Lys:
16
0
0
47
0
8
8
0
0
8
24
0
0
0
8
% K
% Leu:
8
8
0
0
62
0
62
0
0
8
8
0
8
8
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
16
0
8
8
8
0
8
0
0
0
% N
% Pro:
0
0
0
8
0
8
0
0
0
0
8
0
8
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
47
8
8
8
0
0
8
16
0
0
0
0
31
0
0
% R
% Ser:
8
0
8
0
0
0
0
0
31
31
8
8
0
8
47
% S
% Thr:
0
0
0
8
0
0
8
54
16
8
39
0
8
0
8
% T
% Val:
0
8
0
0
8
8
0
0
0
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
8
47
0
0
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _